Skip to main content

All You Need to Know About the Organ-on-a-chip

Organ-on-a-chip is a system which consists of cell culture located in a 3D structure that aids its support, growth as well as proper functioning. Therefore, this device is responsible for mimicking the functions of a particular organ. Yes, you heard it right! A chip which could mimic activities of an organ.


The combination of fluid physics with the 3D compartmentalization of cells plays a significant role in the working of an organ-on-a-chip device.

The microfluidic study focuses on the behaviour of the fluids as well as precisely control and manipulates them through microchannels. Therefore, the principle of microfluidics is applied in order to provide a better environment with the cells which consist of more controlled parameters.

The cells are grown inside the microfluidic chamber in order to create the desired tissue or organs. In order to promote the optimal growth of cells, the chamber should consist of proper nutrients, ambient temperature, pH other parameters. Also, the functionality of the organ should also be maintained by providing specific conditions of for, pH, nutrient contents, toxins, osmotic pressure, etc.

Current Status

It could prove to be a boon for the medical field.  The effect of any external parameter on the functioning of an organ could be precisely studied with the help f the organ-on-a-chip device. Therefore, it could find great applications in the testing of new varieties of the drug on organs. This could be substantiated by the fact after the drugs being tested on animals, they are being subjected to the method of clinical trials on humans. The organ-on-a-chip device could be used to cause a decline in the animal testing methodology and could also be used to replace some part of the clinical trials conducted on humans.

Therefore, this device could help one to study the effect of drugs on human physiology without actually using any animal or human volunteers is currently a major application of this device. Thus, preventing legal complications related to the human as well as animal rights for the pharmaceutical industry.

Different types of organ-on-a-chip systems could be applied in order to study the toxicity or effects associated with a particular drug. Apart from that, it could also hold a great level of application in the research of the diseases that could affect a particular organ like diabetes. Currently, the organ-on-a-chip for lung, heart, gut, skin, kidney and brain could be created in laboratories.

In order to figure out the insights related to the effect of gravity on human physiology, NASA is planning to send a number of these micro-physiological systems into the international space station.


Popular posts from this blog

GMOs: Positive and Negative Impacts

The term GMO is quite common and is gaining significance in a variety of food products. GMO which stands for Genetically Modified Organisms has been a subject of debate ever since it’s discovery among various scientific communities as to whether they are actually advantageous or not. The most common applications GM products are in the food and pharmaceutical industries. However, GMOs can also be used in the environment for its protection and monitoring. Before getting into the impacts of GMOs in various fields it is quite essential to be clear with the concept of GMOs.
What are GMOs? GMOs are basically organisms that are genetically engineered to include a particular trait of another organism or remove certain traits. So basically it is the manipulation of living organisms at the molecular level which is done by using recombinant DNA technology. A gene from one organism is transferred to another one through the use of suitable vectors. The GMO products that find their uses every day …

Biotechnology: A Boon or a Bane

The techniques used to utilize living organisms for the benefit of humans forms the basis of biotechnology. One of the most important question that comes to one's mind while they come to know about biotechnology is that whether it is actually beneficial for us or is it just something which has short term benefits with long term ill effects?

The techniques of biotechnology are as old as 6000 years when the ancient people used fermentation to produce food products. The modern biotechnology is quite a new field with having it's roots around 1971 and therefore it is quite essential to know the pros and cons of it.

Biotechnology: A boon The usefulness of microbes has proved to be a boon in pharmaceutical, agricultural and food processing industries.

Biotechnology has not only helped to modify the agricultural crops for increasing their nutritional aspects but has also increased their yields. Thus, biotechnology has proved to be a boon for the farmers. Genetically modified insectic…

Environmental Biotechnology

Environmental biotechnology is the application of various techniques of biology in order to conserve environment. An environment has always played an essential role in shaping up of an individual whether it is physical or mental health. Thus, it's protection and maintainance is a mandatory duty of every individual. The application of biotechnology in environment has led to the development of environmental biosensors as well as biological waste treatment techniques. It has always tried to provide essential methodologies to improve the quality of an environment.

The application of biotechnology are most prominently in environmental monitoring and waste treatment which are increasing tremendously. Living organisms are manipulated to offer a large range of methodologies that can help in the protection of environment.

Environmental monitoring It includes the set of methodologies that detects alterations in the parameters of environment which in turn indicates the level of pollutants i…